How to Set Up Automatic Replies on Emails from Process Model

We use process models to send a number of emails to our users.  The emails come from addresses like processXXXXX@appiancloud.com.  When a user replies to those emails, the email goes into a black hole.  We would like to set up an automatic reply back to the user letting them know they emailed an unattended mailbox.  As an aside: we cannot change that sending email address as our internal email controls thinks it is a spoofed email and blocks it as it comes into our environment.

Has anyone done this before? If so, how?

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