Getting an error title=Error Calling httpQuery, com.appian.integration.core.exception.ConnectorRuntimeException: Failed to connect http://URL

I'm getting the error below in the server.log. We are making an API call using a!httpQuery()  to retrieve some data, but it failed and we found the error below in the logs. Kindly, please provide some information on what might've caused this issue, additionally whether it is an issue with the server or the service.

 

When we restart the JVM this seems to be connecting fine and the API returns response successfully but after some time it starts throwing the above error. Once the errors starts throwing it doesn't go away until the JVM recycle next time. Really appreciate any ideas as to what's the cause and how to fix this issue/

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