Prevent user from selecting duplicate values in custom picker

I have a custom picker field that returns a list of users, 

 I want to be able to prevent the user from selecting the same user more than once. 

 

 Scenario: 

Users: "John", "James","Sally" 

 

User comes in and selects "John" as a user on the picker field, then presses "j" the only user that should display is "James". How can I achieve this? 

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