Can we install Appian Designer on our local system or on a cloud VM to explore server-level configurations and functionality?
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The appian engines do have a local install, but it's difficult (at least it always was back when I did it occasionally), and requires a special license from Appian that isn't just available to anyone (it has particular opaque customer/licensing concerns, etc). With respect to practicing server-level configs in some other way, I'm not sure what I'd currently suggest. Perhaps email support@appian.com and see what it currently requires to authorize download of the local installer and receiving a license file.
What are you looking for?