Searching from Database with not matching two word

Can't we achieve it through  Querylogic  "AND"  with multiple Queryfilters 

if u r using query record type, u can use list of query filters . if u r using db, u can using logical expression "AND".  

You can try 'not includes' parameter. See the sample code for reference:

filters: a!queryLogicalExpression(
    operator: "AND",
    filters: {
      a!queryFilter(
        field: 'recordType!xxx.fields.abc',
        operator: "not includes",
        value: "CLOS"
      ),
      a!queryFilter(
        field: 'recordType!xxx.fields.abc',
        operator: "not includes",
        value: "CANS"
      )
    },
    ignoreFiltersWithEmptyValues: true
  )

Thanks for your reply. but I want to call like this with single value selection from dropdown like:

filters: a!queryLogicalExpression(
operator: "AND",
filters: {
a!queryFilter(
field: 'recordType!xxx.fields.abc',
operator: "not includes",
value:{ "CLOS", "CANS"}
),
},
ignoreFiltersWithEmptyValues: true
)

So I want to know if it is possible or not or which operation I have to use.

Did you try a forEach?

filters: a!queryLogicalExpression(
    operator: "AND",
    filters: {
        a!forEach(
            items: {"CLOS, "CANS"},
            expression: a!queryFilter(
              field: 'recordType!xxx.fields.abc',
              operator: "not includes",
              value: fv!item
            )
        )
    }
}

Thanks Mathieu.. It is working.

a!queryRecordType(
recordType: recordType!abc,
filters: {
a!queryFilter(
field: recordType!abc.xyz,
operator: "not includes",
value: "CLOS"
),
a!queryFilter(
field: recordType!abc.xyz,
operator: "not includes",
value: "CONS"
)
},
pagingInfo: a!pagingInfo(startIndex: 1, batchSize: 500)
)

-------------------------------------------------------------------------------------
a!queryRecordType(
recordType: recordType!abc,
filters: a!queryLogicalExpression(
operator: "AND",
filters: {
a!queryFilter(
field: recordType!abc.xyz,
operator: "not includes",
value: "CLOS"
),
a!queryFilter(
field: recordType!abc.xyz,
operator: "not includes",
value: "CONS"
)
}
),
pagingInfo: a!pagingInfo(startIndex: 1, batchSize: 500)
)

thanks for suggesting me Konduru Chaitanya 

a!queryRecordType(
recordType: recordType!abc,
filters: {
a!queryFilter(
field: recordType!abc.xyz,
operator: "not includes",
value: "CLOS"
),
a!queryFilter(
field: recordType!abc.xyz,
operator: "not includes",
value: "CONS"
)
},
pagingInfo: a!pagingInfo(startIndex: 1, batchSize: 500)
)

-------------------------------------------------------------------------------------
a!queryRecordType(
recordType: recordType!abc,
filters: a!queryLogicalExpression(
operator: "AND",
filters: {
a!queryFilter(
field: recordType!abc.xyz,
operator: "not includes",
value: "CLOS"
),
a!queryFilter(
field: recordType!abc.xyz,
operator: "not includes",
value: "CONS"
)
}
),
pagingInfo: a!pagingInfo(startIndex: 1, batchSize: 500)
)