Searching from Database with not matching two word

You can try 'not includes' parameter. See the sample code for reference:

filters: a!queryLogicalExpression(
    operator: "AND",
    filters: {
      a!queryFilter(
        field: 'recordType!xxx.fields.abc',
        operator: "not includes",
        value: "CLOS"
      ),
      a!queryFilter(
        field: 'recordType!xxx.fields.abc',
        operator: "not includes",
        value: "CANS"
      )
    },
    ignoreFiltersWithEmptyValues: true
  )

Thanks for your reply. but I want to call like this with single value selection from dropdown like:

filters: a!queryLogicalExpression(
operator: "AND",
filters: {
a!queryFilter(
field: 'recordType!xxx.fields.abc',
operator: "not includes",
value:{ "CLOS", "CANS"}
),
},
ignoreFiltersWithEmptyValues: true
)

So I want to know if it is possible or not or which operation I have to use.

Did you try a forEach?

filters: a!queryLogicalExpression(
    operator: "AND",
    filters: {
        a!forEach(
            items: {"CLOS, "CANS"},
            expression: a!queryFilter(
              field: 'recordType!xxx.fields.abc',
              operator: "not includes",
              value: fv!item
            )
        )
    }
}

Did you try a forEach?

filters: a!queryLogicalExpression(
    operator: "AND",
    filters: {
        a!forEach(
            items: {"CLOS, "CANS"},
            expression: a!queryFilter(
              field: 'recordType!xxx.fields.abc',
              operator: "not includes",
              value: fv!item
            )
        )
    }
}

Thanks Mathieu.. It is working.