How to handle multiple endpoints

no need of creating multiple integration , you can create a text array constant and you can store your endpoint over there and just make sure to call endpoint constant while using that integration in rule or interface !

it really depends on how and what you want to do. If the end points are different they must be doing different operations. if that's the case, then having separate end points might be beneficial. 

I am guessing the request and response for all the end points are different in this case as well