Minor version increments add functionality that is compatible with prior versions of the plug-in. Major version increments will not be compatible with prior versions of the plug-in.
From Appian documentation here: https://docs.appian.com/suite/help/21.1/versioning.html
"When you deploy a new minor version of your connected system, Appian automatically starts using the new version in all connected system and integration objects. Designers don't need to take any action to update existing interfaces unless they want to take advantage of new functionality."
Definitely go through and run some testing, but as long as your plug-in upgrade is just going up in minor version you should be fine.