Refresh page impact on variables

Nothing will happen. The page will refresh.

The page and the related variables will be refreshed as expected...

docs.appian.com/.../refresh-behavior-interfaces.html

If you do a browser refresh, the user will likely lose any progress they have made on that task. For instance, if they had saved some data on a form, that data will not be retained on browser refresh. There will also be a warning message that will show when you attempt to refresh though that mentions that your changes may not be saved.